Alexandria, Va., USA – The International and American Associations for Dental Research (IADR/AADR) have published a Journal of Dental Research special issue on craniofacial stem cells. This special issue of the Journal of Dental Researchencompasses a diverse group of articles that provide a review of important recent advances in craniofacial stem cell biology as well as examples of state-of-the-art research in the field. The issue spans multiple components of the craniofacial complex, from teeth to bones and glands, and it covers both normal development as well as disease processes. The findings from this special issue have implications in the advancement of human oral health in patients suffering from afflictions such as oral cancer, injury or congenital disorders.

The dental articles have a notable focus on the pulp, including mineral tissue formation by dental stem cells (Volponi et al., 2015), regulation of tooth dentin formation by growth factors (Sagomonyants et al., 2015), and the behavior of tooth-related pulp cells (Smith et al., 2015). In addition, stem cells of the human tooth supporting structures are explored (Athanassiou-Papaefthymiou et al., 2015), and other craniofacial organs covered include the salivary gland (Aure et al., 2015; Maruyama et al., 2015) and the temporomandibular (TMJ) joint (Lu et al., 2015). The role of stem cells in diseases of the craniofacial complex is reviewed in a number of the articles (Yin et al., 2015; Chai and Zhao, 2015). New discoveries as well as ongoing challenges involving stem cells in head and neck cancer are covered, and interaction between the immune system and stem cells as well as therapeutic opportunities are discussed (Dionne et al., 2015; Birkeland et al., 2015). Another review focuses on papillomavirus infection and its effect on stem cells of the head and neck region (Pulios et al., 2015). Finally, the issue covers therapeutic strategies in a number of conditions. The current state and future prospects of pulp-dentin regeneration are reviewed (Cao et al., 2015), as is the use of induced pluripotent stem cells (iPSCs) in dentistry (Hynes et al., 2015). Original work explores the molecular basis for cell-based therapy of TMJ osteoarthritis (Lu et al., 2015) and possible uses of dental-derived cells in spinal cord injury repair (De Berdt et al., 2015).

“This issue highlights the impressive advances occurring in the craniofacial stem cell field and demonstrates the enormous promise that stem cell-based therapies hold for the future,” said Special Issue Co-Editor Ophir Klein.

JDR Associate Editor Jacques Nör echoed those sentiments. “I am pleased with the quality of research that is published in this special issue and I am thankful to the authors who chose to submit their research for publication.”

Klein and Nör moderated a podcast, which complements this special issue, with Professors Paul Sharpe and Mark Prince who are internationally-recognized experts in head and neck stem cell biology. Please visit the JDR website atjdr.sagepub.com/site//misc/Index/Podcasts.xhtml to access the podcast. The JDRspecial issue on craniofacial stem cells in oral health and disease is available athttp://jdr.sagepub.com/content/current. Reporters and writers may contact Ingrid L. Thomas at ithomas@iadr.org to request access to the issue. 

IADR/AADR Publish Article on the Global Economic Impact of Dental Diseases

Alexandria, Va., USA – The International and American Associations for Dental Research (IADR/AADR) have published an article titled “Global Economic Impact of Dental Diseases” in the OnlineFirst portion of the Journal of Dental Research. In it, authors Stefan Listl, Jennifer Galloway, Peter Mossey and Wagner Marcenes estimate the direct and indirect costs of dental diseases worldwide.

Reporting the economic burden of oral diseases is important to evaluate the societal relevance of preventing and addressing oral diseases. In addition to treatment costs, there are indirect costs to consider, mainly in terms of productivity losses due to absenteeism from work. Estimation of direct treatment costs was based on a systematic approach.

For estimation of indirect costs, an approach suggested by the World Health Organization’s Commission on Macroeconomics and Health was employed, which factored in 2010 values of gross domestic product per capita as provided by the International Monetary Fund and oral burden of disease estimates from the US Global Burden of Disease Study. Direct treatment costs due to dental diseases worldwide were estimated at US$298 billion yearly, corresponding to an average of 4.6% of global health expenditure. Indirect costs due to dental diseases worldwide amounted to US$144 billion yearly, corresponding to economic losses within the range of the 10 most frequent global causes of death.

Within the limitations of currently available data sources and methodologies, these findings suggest that the global economic impact of dental diseases amounted to US$442 billion in 2010. Improvements in population oral health may imply substantial economic benefits not only in terms of reduced treatment costs but also because of fewer productivity losses in the labor market.

“Through this study, the authors have amplified the message that we need to increase the availability of internationally comparable data on dental treatment costs, disease-specific absenteeism from work and school, as well as intangible costs of oral diseases in terms of quality of life,” said expert and AADR Immediate Past President Timothy DeRouen. “As the community works collaboratively to solve this need, it’s important to stay cognizant of the global economic burden of oral diseases so that we may continue to work toward improving oral health for all populations.”

The article “Global Economic Impact of Dental Diseases” is available in the OnlineFirst portion of the JDR, at http://jdr.sagepub.com. Reporters and writers may contact Ingrid L. Thomas at ithomas@iadr.org to request a PDF.

Brazil’s National Oral Health Policy – An Example for Other Nations

Today, the International and American Associations for Dental Research (IADR/AADR) published a Discovery! article titled “10 Years of a National Oral Health Policy in Brazil: Innovation, Boldness and Numerous Challenges.” In it, authors Gilberto Alfredo Pucca, Jr., University of Brasília; and Mariana Gabriel, Maria Ercilia de Araujo and Fernanda Campos Sousa de Almeida, University of São Paulo, discuss Brazil’s National Policy of Oral Health, also known as “Smiling Brazil.”

Brazil is the only country with more than 200 million inhabitants that has a universal health system, funded by federal, state and municipal budgets. In recent decades, the system has evolved from an exclusionary to a universal model, the unified health system (Sistema Único de Saúde [SUS]), where everyone is entitled to healthcare and the government is required to provide it. Primary healthcare is the backbone of the new system, in keeping with the guidelines set forth by the Primary Healthcare Reform, recommended by the Pan American Health Organization/World Health Organization.

Continue reading

IADR/AADR Publish Sixth Clinical Supplement to the Journal of Dental Research

The International and American Associations for Dental Research (IADR/AADR) have just released the sixth clinical supplement to the Journal of Dental Research (JDR). This clinical supplement encompasses all areas of clinical research in the dental, oral and craniofacial sciences.

As the second clinical supplement to be published this year, this sixth supplement brings together emerging contributions in discovery and translational science to clinical application for the healthcare community. This issue is dedicated to clinical and translational research, which is covered through a wide range of topics including the promises and pitfalls in the use of “Big Data” for clinical research, the use of a computerized tool to manage dental anxiety, periodontal bacteria and prevalent prediabetes, and more.

This clinical supplement also includes a companion podcast for two manuscripts: “3D-printed Bioresorbable Scaffold for Periodontal Repair” and “3D Bioprinting for Regenerative Dentistry and Craniofacial Tissue Engineering.” In this podcast, Drs. Scott Hollister and Luiz Bertassoni are interviewed by Associate Editor Dana Graves on different approaches to 3D printing, challenges, regulation and clinical application.

Continue reading

The IADR/AADR JDR Ranks #1 in the Two-Year Journal Impact Factor

Alexandria, Va., USA – Today, the International and American Associations for Dental Research announced that the Journal of Dental Research (JDR) ranks #1 with a two-year Journal Impact Factor of 4.139 in the “Dentistry, Oral Surgery & Medicine” category. This news comes from the 2015 Release of Journal Citation Reports® with “Source: 2014 Web of Science™ Data”.

Journal Impact Factors are a measure of the frequency with which the average article in a journal has been cited in a particular year. The impact factor helps to evaluate a journal’s relative importance, especially when compared with others in the same field.

“I am pleased that the JDR has advanced to #1 in our field,” said JDR Editor William Giannobile. “This news comes on the heels of the JDR’s updated look and the launch of an updated subtitle: the journal for dental, oral and craniofacial research, which emphasizes the broad scope of the Journal. This is an exciting time for the JDR and I am thankful to the scientists who continue to submit their research to the JDR for publication.”

Continue reading

2014 JDR Year in Review

I am delighted to update the readership on our 2014 year in review. This report gives a status update on progress the JDR over the past nearly 5 years as well. I feel that the journal has been able to continue to improve as a leading source of scientific information in the oral, dental and craniofacial sciences.   The JDR remains ranked # 1/82 journals in Dentistry for Eigenfactor™ Score at 0.2235 and #2/82 journals in 2-year impact factor at 4.144, the first time the journal has exceeded 4 for SIF.  We feel the journal remains strong not only in these metrics, but also in other important measures of success including numbers of full-text downloads, page views, article influence score among other metrics.


The journal owes much of this success to several key individuals who support the JDR on a daily basis including Dr. Christopher Fox, Denise Streszoff, Kourtney Skinner and Lily Knol at the JDR Headquarters in Alexandria. The editors are also fortunate to be supported by the capable staff at SAGE Publishing, in particular, Paulina Klein and Courtney Pugh, who have done an fine job in developing a strong working relationship between the IADR/AADR Central Offices and SAGE to sustain the excellence of JDR. Ms. Karen Gardner as the local editorial assistant at the University of Michigan helps me on the day-to-day administration of the JDR with the careful management of manuscript page proofs among the authors, our office and SAGE. I am also very grateful for the excellent progress the associate editors of the journal have made: (Professor Dana Graves as Associate Editor for Critical Reviews in Oral Biology and Medicine) and for Professors Jack Ferracane Nicola Innes, Jessica Lee, Jacques Nör and Joy Richman as AEs. I am highly appreciative of the excellent management of challenging manuscript decisions given that JDR’s acceptance rate remains at ~10% on research reports that have continued to increase each year since 2010 (see below). Further, based on data from the recent JDR author satisfaction survey from 2012, we find that the submitting authors having their papers accepted and published in the JDR are generally satisfied with the quality and timeliness of publication of their research.

In the following are some more significant accomplishments of the JDR for 2014: Continue reading

JDR releases first Podcast

The Journal of Dental Research has recorded and released its first podcast. The podcast contains a question & answer session between Editor-in-Chief, Dr. William V. Giannobile and Dr. Hal Slavkin, author of the July article, “From Phenotype to Genotype: Enter Genomics and Transformation of Primary Health Care around the World.” You can listen to the podcast here.